Cellular communication through exosomes in the tumor microenvironment
DOI:
https://doi.org/10.70577/t47rnb55Keywords:
exosomes, tumor microenvironment, cellular communication, microRNA, tumor progressionAbstract
The complexity of the tumor microenvironment limits the understanding of cellular communication mechanisms, particularly the role of exosomes in cancer progression. The objective was to analyze exosome-mediated cellular communication and its influence on tumor dynamics. A quantitative, non-experimental, correlational approach was applied, based on a systematic review of scientific sources and international organizations from 2021 to 2023, using Pearson correlation and multiple linear regression. The results showed a strong positive correlation (r = 0.82) between exosome concentration and tumor progression, as well as significant explanatory power of exosomal microRNAs (R² = 0.68) in cancer aggressiveness. An increase of up to 35% in cellular invasion and a 28% reduction in apoptosis were also identified, confirming their role in metastasis and therapeutic resistance. Consequently, exosomes are established as key mediators in tumor microenvironment reprogramming and as a basis for developing diagnostic and therapeutic strategies.
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