Cytoskeleton and cell migration in metastasis processes
DOI:
https://doi.org/10.70577/8jep7z32Keywords:
cytoskeleton, cell migration, metastasis, epithelial mesenchymal transition, tumor microenvironmentAbstract
Metastasis is a complex process in which cell migration plays a decisive role, largely conditioned by cytoskeletal dynamics. The objective was to analyze the relationship between cytoskeletal reorganization and the migratory capacity of tumor cells. A quantitative approach with a non experimental design was applied, based on scientific literature and reports from national and international organizations, using Spearman correlation, multiple linear regression, and LASSO. The findings highlight a direct association between actin reorganization, focal adhesion activity, and cell migration, identifying cytoskeletal proteins as the most influential factor. Additionally, epithelial mesenchymal transition and biomechanical conditions of the microenvironment were shown to enhance cellular plasticity and increase invasive capacity. These results confirm that metastatic migration responds to an integrated system involving structural, molecular, and physical factors, positioning the cytoskeleton as a central axis in tumor dissemination.
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Ahmad, M., Weiswald, L.-B., Poulain, L., Denoyelle, C., & Meryet-Figuiere, M. (2023). Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk. Journal of Experimental & Clinical Cancer Research, 42(1), 173. doi:10.1186/s13046-023-02741-x
Datta, A., Deng, S., Gopal, V., Yap, K. C. H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., & Sethi, G. (2021). Cytoskeletal dynamics in epithelial-mesenchymal transition: Insights into therapeutic targets for cancer metastasis. Cancers, 13(8), 1882. doi:10.3390/cancers13081882
de la Cruz Concepción, B., Bartolo-García, L. D., Tizapa-Méndez, M. D., Martínez-Vélez, M., Valerio-Diego, J. J., Illades-Aguiar, B., Salmerón-Bárcenas, E. G., Ortiz-Ortiz, J., Torres-Rojas, F. I., Mendoza-Catalán, M., et al. (2022). EMMPRIN is an emerging protein capable of regulating cancer hallmarks. European Review for Medical and Pharmacological Sciences, 26(18), 6700–6724. doi:10.26355/eurrev_202209_29771
Díaz-Valencia, J. D., Estrada-Abreo, L. A., & Chávez-Munguía, B. (2022). Class I myosins, molecular motors involved in cell migration and cancer. Cell Adhesion & Migration, 16(1), 1–12. doi:10.1080/19336918.2021.2020705
González, I., Luzuriaga, J., Valdivieso, A., Candil, M., Frutos, J., López, J., Hernández, L., Rodríguez-Lorenzo, L., Yagüe, V., Blanco, J. L., Pinto, A., & Earl, J. (2023). Low-intensity continuous ultrasound to inhibit cancer cell migration. Frontiers in Cell and Developmental Biology, 10, 842965. doi:10.3389/fcell.2022.842965
Guerrero-Rodríguez, S. L., Mata-Cruz, C., Pérez-Tapia, S. M., & Velasco-Velázquez, M. A. (2022). Role of CD36 in cancer progression, stemness, and targeting. Frontiers in Cell and Developmental Biology, 10, 1079076. doi:10.3389/fcell.2022.1079076
Herrera-Quiterio, G. A., & Encarnación-Guevara, S. E. (2023). The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Frontiers in Oncology, 13, 1244740. doi:10.3389/fonc.2023.1244740
Juste-Lanas, Y., Guerrero, P. E., Camacho-Gómez, D., Hervás-Raluy, S., García-Aznar, J. M., & Gómez-Benito, M. J. (2022). Confined cell migration and asymmetric hydraulic environments to evaluate the metastatic potential of cancer cells. Journal of Biomechanical Engineering, 144(7), 074502. doi:10.1115/1.4053143
Leggett, S. E., Hruska, A. M., Guo, M., & Wong, I. Y. (2021). The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems. Cellular and Molecular Life Sciences, 78, 3907–3934. doi:10.1007/s00018-021-03713-2
Lobos-González, L., Oróstica, L., Díaz-Valdivia, N., Rojas-Celis, V., Campos, A., Duran-Jara, E., Farfán, N., Leyton, L., & Quest, A. F. G. (2023). Prostaglandin E2 exposure disrupts E-cadherin/Caveolin-1-mediated tumor suppression to favor Caveolin-1-enhanced migration, invasion, and metastasis in melanoma models. International Journal of Molecular Sciences, 24(23), 16947. doi:10.3390/ijms242316947
Matter, M. L., & Gkretsi, V. (2023). Editorial: Molecular regulation of tumor cells migration and metastatic growth. Frontiers in Oncology, 13, 1329053. doi:10.3389/fonc.2023.1329053
Matter, M. L., & Gkretsi, V. (2023). Molecular regulation of tumor cells migration and metastatic growth. Frontiers in Oncology, 13, 1329053. doi:10.3389/fonc.2023.1329053
Muñoz-Sáez, E., Moracho, N., Learte, A. I. R., Collignon, A., Arroyo, A. G., Noel, A., Sounni, N. E., & Sánchez-Camacho, C. (2023). Molecular mechanisms driven by MT4-MMP in cancer progression. International Journal of Molecular Sciences, 24(12), 9944. doi:10.3390/ijms24129944
Oregel-Cortez, M. I., Frayde-Gómez, H., Quintana-González, G., García-González, V., Vázquez-Jiménez, J. G., & Galindo-Hernández, O. (2023). Resistin induces migration and invasion in PC3 prostate cancer cells: Role of extracellular vesicles. Life, 13(12), 2321. doi:10.3390/life13122321
Ortiz-Soto, G., Babilonia-Díaz, N. S., Lacourt-Ventura, M. Y., Rivera-Rodríguez, D. M., Quiñones-Rodríguez, J. I., Colón-Vargas, M., Almodóvar-Rivera, I., Ferrer-Torres, L. E., Suárez-Arroyo, I. J., & Martínez-Montemayor, M. M. (2023). Metadherin regulates inflammatory breast cancer invasion and metastasis. International Journal of Molecular Sciences, 24(5), 4694. doi:10.3390/ijms24054694
Pacheco-Velázquez, S. C., Ortega-Mejía, I. I., Vargas-Navarro, J. L., Padilla-Flores, J. A., Robledo-Cadena, D. X., Tapia-Martínez, G., Peñalosa-Castro, I., Aguilar-Ponce, J. L., Granados-Rivas, J. C., Moreno-Sánchez, R., & Rodríguez-Enríquez, S. (2022). 17-β estradiol up-regulates energy metabolic pathways, cellular proliferation and tumor invasiveness in ER+ breast cancer spheroids. Frontiers in Oncology, 12, 1018137. doi:10.3389/fonc.2022.1018137
Palafox-Mariscal, L. A., Ortiz-Lazareno, P. C., Jave-Suárez, L. F., Aguilar-Lemarroy, A., Villaseñor-García, M. M., Cruz-Lozano, J. R., González-Martínez, K. L., Méndez-Clemente, A. S., Bravo-Cuellar, A., & Hernández-Flores, G. (2023). Pentoxifylline inhibits TNF-α/TGF-β1-induced epithelial-mesenchymal transition via suppressing the NF-κB pathway and SERPINE1 expression in CaSki cells. International Journal of Molecular Sciences, 24(13), 10592. doi:10.3390/ijms241310592
Parlani, M., Sánchez-Magraner, L., & Martínez-Torres, C. (2023). Plasticity of cancer invasion and energy metabolism. Trends in Cell Biology, 33(2), 159–172. doi:10.1016/j.tcb.2022.10.005
Solís-Fernández, G., Montero-Calle, A., Martínez-Useros, J., de los Ríos, V., Sanz, R., Dziakova, J., Milagrosa, E., Fernández-Aceñero, M. J., Peláez-García, A., Casal, J. I., Hofkens, J., Rocha, S., & Barderas, R. (2022). Spatial proteomic analysis of isogenic metastatic colorectal cancer cells reveals key dysregulated proteins associated with lymph node, liver, and lung metastasis. Cells, 11(3), 447. doi:10.3390/cells11030447
Solís-Fernández, G., Montero-Calle, A., Sánchez-Martínez, M., Peláez-García, A., & Barderas, R. (2022). Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis. British Journal of Cancer, 126(11), 1604–1615. doi:10.1038/s41416-022-01762-1
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